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'<img alt="" src="/uploads/allimg/170424/3-1F424111004409.jpg" style="width: 600px; height: 844px;" /><br />
<p style="margin: 0px 0px 1em; padding: 0px; text-indent: 2em; color: rgb(37, 37, 37); font-family: 微軟雅黑, "microsoft yahei", Arial, sans-serif; font-size: 16px;">
2017年4月23日訊 /生物谷BIOON /——一篇關於咖啡因安全的嚴謹的新科學系統性綜述文章證實了廣泛引用的加拿大衛生部文獻綜述（2003）的結果，該綜述得出瞭如下結論：成人≤400 毫克/天的咖啡因攝入量與嚴重健康副作用（也就是每天4杯咖啡）無關。90%美國人通常的消耗少於此量，其中孕婦≤300毫克/天，兒童和青少年每天≤2.5 毫克/千克。這些發現出於近日發表在Food and Chemical Toxicology雜誌上，同時，這些成果於近日在芝加哥實驗生物學會議上進行了展示。</p>
<p style="margin: 0px 0px 1em; padding: 0px; text-indent: 2em; color: rgb(37, 37, 37); font-family: 微軟雅黑, "microsoft yahei", Arial, sans-serif; font-size: 16px;">
自2003年以來，已經發表了超過10000篇與咖啡因相關的論文。但是同行評議文獻中，依然沒有發現與咖啡因消耗相關健康影響的強有力、透明和系統的評估。因此，北美國際生命科學學會（IL SI）決定綜述2001-2015年相關研究的數據。</p>
<p style="margin: 0px 0px 1em; padding: 0px; text-indent: 2em; color: rgb(37, 37, 37); font-family: 微軟雅黑, "microsoft yahei", Arial, sans-serif; font-size: 16px;">
進行此次研究綜述的研究人員得出結論，健康咖啡因消費者中按照此前確定的咖啡因攝入水平攝入咖啡因與明顯不良反應無關。這表明研究人員還需要在不健康人羣、敏感人羣和個體間做進一步研究。</p>
<p style="margin: 0px 0px 1em; padding: 0px; text-indent: 2em; color: rgb(37, 37, 37); font-family: 微軟雅黑, "microsoft yahei", Arial, sans-serif; font-size: 16px;">
“這篇系統綜述提供的證據進一步加深了咖啡因對人類健康影響的理解。“北美ILSI執行主任Eric Hentges博士說。“此外，這篇綜述也爲研究界提供了大量的數據和寶貴的證據，以支持未來對影響大衆健康的咖啡因安全性研究的開發和執行。數據共享的完全透明度將鼓勵其他研究人員參與此研究”</p>
<p style="margin: 0px 0px 1em; padding: 0px; text-indent: 2em; color: rgb(37, 37, 37); font-family: 微軟雅黑, "microsoft yahei", Arial, sans-serif; font-size: 16px;">
利用國家科學院醫學研究所“系統評議標準”，研究人員認真分析了740多項研究，評估了在急性毒性、骨/鈣、心血管、行爲和生殖與發展5個與咖啡因相關方面的不良健康結果。與IOM標準一致，研究團隊由一名來自爲私人和公共組織提供毒理學和風險評估的私人諮詢公司-Tox Strategies的研究人員和7名來自科學顧問委員會（SAB）、具有多種專業知識的成員組成。</p>
<p style="margin: 0px 0px 1em; padding: 0px; text-indent: 2em; color: rgb(37, 37, 37); font-family: 微軟雅黑, "microsoft yahei", Arial, sans-serif; font-size: 16px;">
所有與文獻審查與分級相關的數據在衛生保健研究和質量管理機構系統評議數據儲存中心開放，同時每一項健康結果的操作都可以在PROSPERO註冊評價系統中索取。（生物谷Bioon.com）</p>
<p style="margin: 0px 0px 1em; padding: 0px; text-indent: 2em; color: rgb(37, 37, 37); font-family: 微軟雅黑, "microsoft yahei", Arial, sans-serif; font-size: 16px;">
<span style="margin: 0px; padding: 0px; font-weight: bold;">原文出處：</span></p>
<p style="margin: 0px 0px 1em; padding: 0px; text-indent: 2em; color: rgb(37, 37, 37); font-family: 微軟雅黑, "microsoft yahei", Arial, sans-serif; font-size: 16px;">
<span style="margin: 0px; padding: 0px; font-weight: bold;">Daniele Wikoff, Brian T. Welsh, Rayetta Henderson et al.<a href="http://www.sciencedirect.com/science/article/pii/S0278691517301709" style="margin: 0px; padding: 0px; text-decoration: none; color: rgb(201, 22, 24); outline: none; word-wrap: break-word; word-break: break-all;">Systematic review of the potential adverse effects of caffeine consumption in healthy adults,</a>pregnant women, adolescents, and children. Food and Chemical Toxicology. doi.org/10.1016/j.fct.2017.04.002</span></p>
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